2000 - PRESENT
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Original Articles in Peer-Reviewed Journals
Title
Author(s)
Journal
Publication
Year
2010 Malpighi Award Lecture Ley, K.
2010
Rolling on E- or P-selectin induces the extended, but not high affinity conformation of LFA-1 in neutrophils. Kuwano, Y., Spelten, O., Zhang, H., Ley, K., Zarbock, A.
Blood 2010
The transmembrane domains of L-selectin and CD44 regulate receptor cell surface positioning and leukocyte adhesion under flow. Buscher, K., Riese, S.B., Shakibaei, M., Reich, C., Dernedde, J., Tauber, R., Ley, K.
Journal of Biological Chemistry 2010
Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin 17 production. von Vietinghoff, S., Ouyang, H., Ley, K.
Kidney International 2 2010
CXCL4 induces a unique transcriptome in monocyte-derived macrophages. Gleissner, G.A., Shaked, I., Little, K.M., Ley, K.
Journal of Immunology 2010
Blockade of IL-17A results in reduced atherosclerosis in Apoe-deficient mice. Smith, E., Prasad, K.R., Butcher, M., Dobrian, A., Kolls, J.K., Ley, K., Galkina, E.
Circulation 2010
Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) ?2 and PI3K? pathways. Mueller, H., Stadtmann, A. Zhang, H., Van Aken, H., Hirsch, E. Wang, D., Ley, K., Zarbock A.
Blood 2010
Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis – implications for thrombus formation. Schulz, C., Leuschen, N.V., Fröhlich, T., Lorenz, M., Pfeiler, S., Gleissner, C.A., Kremmer, E., Kessler, M., Khandoga, A.G., Engelmann, B., Ley, K., Massberg, S., Arnold, G.J.
Blood. 2010
CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages. Gleissner, C.A., Shaked, I., Erbel, C., Böckler, D., Katus, H.A., Ley, K.
Circulation Research 2010
ReSASC: A Resampling-Based Algorithm to Determine Differential Protein Expression from Spectral Count Data. Little, K.M., Lee, J.K., Ley, K.
Proteomics 2010
PI3K ? required for LPS-induced transepithelial neutrophil trafficking in the lung. Reutershan, J., Saprito, M.S., Wu, D., Rückle, T., Ley, K.
European Respiratory Journal. 2009
T-lineage cells require the thymus, but not V(D)J recombination to produce IL-17A and regulate granulopoiesis in vivo. Smith, E., von Vietinghoff, S., Stark, M.A., Zarbock, A., Sanders, J.M.., Duley, A., Rivera-Nieves, J., Bender, T.P., Ley, K.
Journal of Immunology 2009
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). Zarbock, A., DiStasi, M.R., Smith, E., Sanders, J.M., Kronke, G, Harry, B., von Vietinghoff, S., Buscher, K., Nadler, J.L., Ley, K.
J. Immunol. 2009
Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow. Ferrante, E.A., Pickard, J.E., Ryckak, J.J., Klibanov, A.S., Ley, K.
Journal of Controlled Release 2009
Micro-PTV measurement of the fluid shear stress acting on adherent leukocytes in vivo. Pickard, J.E., Ley, K.
Biophys. J. 2009
DARC on red blood cells limits lung injury by balancing compartmental distribution of CXC chemokines. Reutershan, J., Harry, B., Chang, D., Bagby, G.J., Ley, K.
European Journal of Immunology 2009
Interleukin 17A controls Interleukin 17F production and maintains blood neutrophil counts in mice. von Vietinghoff, S., Ley, K.
J. Immunol. 2009
Dynamics of Microvillus Extension and Tether Formation in Rolling Leukocytes. Pospieszalska, Ley, K.
Cellular and Molecular Bioengineering 2009
Role of β7 integrins in intestinal lymphocyte homing and retention. Gorfu, G., Rivera-Nieves, J., Ley, K.
Current Molecular Medicine 2009
Glycans in immune cell trafficking. Sperandio, M., Ley, K.
Immunological Reviews 2009
The role of platelets in acute lung injury (ALI). Zarbock, A., Ley, K.
Frontiers in Bioscience 2009
CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury Li G, Sanders JM, Bevard MH, Sun Z, Chumley JW, Galkina EV, Ley K, Sarembock IJ
Am J Pathol 2008
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM-adapters DAP12 and FcRγ to induce slow leukocyte rolling Zarbock, A., Abram, C.L., Hundt, M., Altman, A., Lowell, C.A., Ley, K.
J. Exp. Med 2008
Transcriptional Regulation of mouse L-Selectin Dang, X., Raffler, N.A., K. Ley
Biochim Biophys Acta 2009
Event tracking model of adhesion identifies load-bearing bonds in leukocyte rolling Pospieszalska, M.K., Zarbock, A., Pickard, J.E., Ley, K.
Microcirculation 2009
Mechanisms and consequences of neutrophil interaction with the endothelium Zarbock, A., Ley, K.
Biological Perspectives Series, Am. J. Pathol 2008
Plasma-derived microparticles for biomarker discovery Smalley, D.M, Ley, K.
Clinical Laboratory 2008
Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells Alon, R., Ley, K.
Current Opinion in Cell Biology 2008
Neutrophil adhesion and activation under flow Zarbock, A., Ley, K.
Microcirculation 2008
Leukocyte adhesion molecules in animal models of Inflammatory Bowel Disease Rivera-Nieves, J., Gorfu, G., Ley, K.
Inflammatory Bowel Diseases 2008
Homeostatic regulation of blood neutrophil counts Vietinghoff, S., Ley, K.
J. Immunol. 2008
Immune and inflammatory mechanisms of atherosclerosis Galkina, E., Ley, K.
Ann. Rev. Immunology 2009
Monocyte-Endothelial Cell Interactions in the Development of Atherosclerosis Mestas, J., Ley, K.
Trends Cardiovasc Med 2009
Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms Ley, K. and Zhang, H.
J.Cell Biol 2008
Event tracking model of adhesion identifies load-bearing bonds in leukocyte rolling 13. Pospieszalska, M.K., Zarbock, A., Pickard, J.E., Ley, K.
Microcirculation 2009
Endothelial Cell PECAM-1 Promotes Atherosclerotic
Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice Brian L. Harry, John M. Sanders, Ryan E. Feaver, Melissa Lansey, Tracy L. Deem,
Alexander Zarbock, Anthony C. Bruce, Andrew W. Pryor, Bradley D. Gelfand, Brett R. Blackman,
Martin A. Schwartz, Klaus Ley
ATVB 2008
Platelet Chemokines in Vascular Disease Christian A. Gleissner, Philipp von Hundelshausen and Klaus Ley
ATVB 2008
PECAM-1-dependent endothelial shear stress response promotes atherosclerotic lesions in areas of disturbed flow. Harry, B.L., Lansey, M., Sanders, J.M., Bruce, A., Pryor, A.W., Gelfand, B.D., Blackman, B.R., Schwartz, M.A., Ley, K.
ATVB PMID 2008
Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury (ALI) in mice. Zarbock, A., Allegretti, M., Ley, K.
Br. J. Pharmacol. 2008
Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. Frommhold, D., Ludwig, A., Bixel, M.G., Zarbock, A., Babushkina, I., Weissinger, M., Cauwenbergs, S., Ellies, L.G., Marth, J.D., Beck-Sickinger, A.G., Sixt, M., Lange-Sperandio, B., Zernecke, A., Brandt, E., Weber, C., Vestweber, D., Ley, K., and Sperandio, M.
J. Exp. Med 2008
Interleukin-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor. Smith, E., Stark, M.A., Zarbock, A., Burcin, T.L., Bruce, A., Vaswani, D. Foley, P., Ley, K.
J. of Immunology 2008
Upregulation of aldose reductase during foam cell formation as possible link between diabetes, hyperlipidemia and atherosclerosis. Gleissner, C., Sanders, J.M., Nadler, J.L., Ley, K.
ATVB 2008
Blockade of CD40L signaling attenuates leukocyte accumulation and neointima formation after carotid denudation injury in apolipoprotein E-deficient mice. Li G, Sanders JM, Bevard MH, Chumley JW, Galkina EV, Ley K, Sarembock IJ.
Am.J.Pathol. 2008
Neutrophil p21-activated kinase is critically involved in LPS-induced acute lung injury. Reutershan, J., Stockton, R., Zarbock, A., Sullivan, G.W., Chang, D., Scott, D., Schwartz, M.A., Ley, K.
American Journal of Respiratory and Critical Care Medicine 2007
Interleukin-23 is required for neutrophil homeostasis in normal and neutrophilic mice. Smith, E., Zarbock, A., Stark, M.A., Burcin, T.L., Bruce, A.C., Foley, P., Ley, K.
Journal of Immunology 2007
Initiation of Protein O-Glycosylation by Polypeptide GalNAcT-1 in Vascular Biology and Humoral Immunity Tenno, M., Ohtsubo, K., Hagen, F.K., Ditto, D., Zarbock, A., Schaerli, P., von Andrian, U.H., Ley, K., Le, D., Tabak, L.A., Marth, J.D.
Mol. Cell. Biol. 2007
CXCR6 Promotes Atherosclerosis by Supporting T-Cell Homing, Interferon-{gamma} Production, and Macrophage Accumulation in the Aortic Wall. Galkina E, Harry BL, Ludwig A, Liehn EA, Sanders JM, Bruce A, Weber C, Ley K.
Circulation 2007
Statistical identification of differentially labeled peptides from liquid chromatography tandem mass spectrometry. Cho H, Smalley DM, Theodorescu D, Ley K, Lee JK.
Proteomics 2007
The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation. Zarbock A, Schmolke M, Bockhorn SG, Scharte M, Buschmann K, Ley K, Singbartl K.
Crit Care Med .2007
G{alpha}i2 is required for chemokine-induced neutrophil arrest. Zarbock A, Deem TL, Burcin TL, Ley K.
Blood 2007
The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal MD chemokine presentation. Zarbock, Alexander MD; Schmolke, Mirco PhD; Bockhorn, Susanne Groe PhD; Scharte, Marion MD; Buschmann, Kirsten MD; Ley, Klaus MD; Singbartl, Kai MD
Crit Care Med .2007
Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury. Jörg Reutershan, Rebecca E. Cagnina, Daniel Chang, Joel Linden, and Klaus Ley
J Immunol .2007
Enhanced targeting of ultrasound contrast agents using acoustic radiation force. J. Rychak, A. Klibanov, K. Ley, J. Hossack
Ultrasound Med Biol .2007
Spleen Tyrosine Kinase Syk Is Necessary
for E-Selectin-Induced AlphaLBeta2 Integrin-Mediated Alexander Zarbock, Clifford A. Lowell, and Klaus Ley
Immunity
2007
Induction of Vascular Permeability: betaPIX and GIT1 Scaffold the Activation of Extracellular Signal-regulated Kinase by PAK. Rebecca Stockton, Jörg Reutershan, David Scott, John Sanders, Klaus Ley, and Martin Alexander Schwartz
Mol. Biol. Cell
2007
Blocking p21-activated Kinase Reduces Lipopolysaccharide-induced Acute Lung Injury by Preventing Polymorphonuclear Leukocyte Infiltration. Jörg Reutershan, Rebecca Stockton, Alexander Zarbock, Gail W. Sullivan, Daniel Chang, David Scott, Martin A. Schwartz, and Klaus Ley
Am. J. Respir. Crit. Care Med.
2007
Dynamics of in silico leukocyte rolling, activation, and adhesion. Jonathan Tang, Klaus F Ley and C Anthony Hunt
BMC Syst Biol.
2007
ENHANCED TARGETING OF ULTRASOUND CONTRAST AGENTS USING ACOUSTIC RADIATION FORCE. J. Rychak, A. Klibanov, K. Ley, J. Hossack
Ultrasound in Medicine & Biology
2007
Induction of Dendritic Cell-like Phenotype in Macrophages during Foam Cell Formation. HyungJun Cho, Pavel Shashkin, Christian Albert Gleissner, Dane Morris Dunson, Nitin Jain, Jae Lee, Yury Miller, and Klaus Ley
Physiol. Genomics
2007
Proteomic discovery of 21 proteins expressed in human plasma-derived but not platelet-derived microparticles David M. Smalley, Karen E. Root, HyungJun Cho, Mark M. Ross, Klaus Ley
Thrombosis and Haemostasis
2007
Markus Sperandio, M.D., David Frommhold, Inna Babushkina, Lesley G. Ellies, Timothy S. Olson, Michael L. Smith, Benedikt Fritzsching, Eva Pauly, David F. Smith, Rainer Nobiling, Otwin Linderkamp, Jamey D. Marth, Klaus Ley
European Journal of Immunology
2006
Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation
Alexander Zarbock, Kai Singbartl and Klaus Ley
J. Clin. Invest. 2006
Leukocyte phosphoinositide-3 kinase
David F. Smith, Tracy L. Deem, Anthony C. Bruce, Jörg Reutershan, Daniel Wu and Klaus Ley
Journal of Leukocyte Biology
2006
Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow A. L. Klibanov , J. J. Rychak, W. C. Yang, S. Alikhani, B. Li, S. Acton, J. R. Lindner, K. Ley, S. Kaul
Contrast Media & Molecular Imaging
2006
Antibody Blockade of CCL25/CCR9 Ameliorates Early but not Late Chronic Murine Ileitis. J. Rivera–Nieves, J. Ho, G. Bamias, N. Ivashkina, K. Ley, M. Oppermann, F. Cominelli
Gastroenterology
2006
Platelet-neutrophil-interactions: Linking hemostasis and inflammation. A. Zarbock, R. Polanowska-Grabowska, K. Ley
Blood Reviews
2006
Sphingosine-1 Phosphate Prevents Monocyte/Endothelial Interactions in Type 1 Diabetic NOD Mice Through Activation of the S1P1 Receptor
Angela M. Whetzel, David T. Bolick, Suseela Srinivasan, Timothy L. Macdonald, Margaret A. Morris, Klaus Ley, Catherine C. Hedrick
Circulation Research
2006
Deformable gas-filled microbubbles targeted to P-selectin Joshua J. Rychak, Jonathan R. Lindner, Klaus Ley, and Alexander L. Klibanov
Journal of Controlled Release
2006
Selectin ligands promote ultrasound contrast agent adhesion under shear flow. J. J. Rychak, B. Li, S. T. Acton, A. Leppänen, R. D. Cummings, K. Ley, and A. L. Klibanov
Mol. Pharmaceutics
2006
Hold on to Your Endothelium: Postarrest Steps of the Leukocyte Adhesion Cascade Klaus Ley and Alexander Zarbock
Immunity
2006
Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. Galkina, E., Kadl, A., Sanders, J., Varughese, D., Sarembock, I.J., Ley K.
J. Exp. Med.
2006
ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into alveolar space. Basit A, Reutershan J, Morris MA, Ley K.
Am.J. Physiol: Lung Cell. Mol. Physiol
2006
Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung. Reutershan, J., Morris, M.A. Burcin, T.L. Smith, D.F., Chang, D. Saprito, M.S., Ley, K.
J. Clin. Invest.
2006
Critical role of endothelial PSGL-1 in chronic murine ileitis. Rivera-Nieves, J., Burcin, T., Olson, T.S., Morris, M.A., McDuffie, M., Cominelli, F., Ley, K.
J. Exp. Med.
2006
The primary defect in experimental ileitis originates from a non-hematopoietic source. Olson TS, Morris MA, Scott KGE, Reuter BK, Brucin TL, Hancock LN, Meddings JB, Cominelli F, Ley K, Pizarro TT
J. Exp. Med.
2006
Protective Effects of Isoflurane Pretreatment in Endotoxin-induced Lung Injury. Reutershan, J., Hayes, J., Ley, K.
Anesthesiology
2006
Targeting Mucosal Addressin Cellular Adhesion Molecule (MAdCAM)-1 to Non-Invasively Image Experimental Crohn's Disease. Bachmann, C., Klibanov, A.L., Olson, T.S., Cominelli, F., Ley, K., Lindner, J.R., Pizarro, T.T.
Gastroenterology
2006
Induction of LFA-1-dependent neutrophil rolling on ICAM-1 by engagement of E-selectin. Chesnutt, B.C., Smith, D.F., Raffler, N.A., Smith, M.L., White, E.J., Ley, K.
Microcirculation
2006
Protection from ileitis maps to PPAR? in mice. Sugawara K, Olson T, Moskaluk CA, Stevens B, Hoang S, Kozaiwa K, Cominelli F, Ley K, McDuffie M.
Gastroenterology
2005
Preferential migration of effector CD8+ T-cells into the interstitium of the normal lung. Galkina, E., Thatte, J., Dabak, V., Williams, M.B., Ley, K., Braciale, T.J.
J. Clin. Invest.
2005
Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720. Morris, M.A., Gibb D.R., Brinkmann, V., Straume, M., Ley, K.
Eur. J. Immunol.
2005
Arterial Macrophages and Regenerating Endothelial Cells Express P-selectin in Atherosclerosis-Prone Apolipoprotein E-Deficient Mice. Li, G., Sanders, J.M., Phan, E.T., Ley, K., Sarembock, I.J.
Am J. Pathol.
2005
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. Kharel, Y., Lee, S., Snyder, A.H., Sheasley-O’Neill, S.L., Morris, M.A., Setiady, Y., Zhu, R., Zigler, M.A., Burcin, T.L., Ley, K., Tung, K.S.K., Engelhard, V.H., Macdonald, T.L., Lynch, K.R.
J. Biol. Chem.
2005
The Platelet Microparticle Proteome. Garcia, B.A., Smalley, D.M., Cho, H., Shabanowitz, J., Ley, K., Hunt, D.F.
J Proteome Res.
2005
Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease. Sugawara K, Olson T, Moskaluk CA, Stevens B, Hoang S, Kozaiwa K, Cominelli F, Ley K, McDuffie M.
Gastroenterology
2005
Sequential
recruitment of neutrophils into lung and bronchoalveolar
lavage fluid in LPS-induced acute lung injury. Reutershan J, Basit A,
Galkina EV, Ley K.
Am J Physiol Lung Cell
Mol Physiol.
2005
GRO
Family Chemokines are Specialized for Monocyte Arrest
from Flow. Smith DF, Galkina E, Ley
K, Huo Y.
Am J Physiol Heart Circ
Physiol.
2005
Phagocytosis
of apoptotic neutrophils regulates granulopoiesis via
IL-23 and IL-17. Stark MA, Huo Y, Burcin
TL, Morris MA, Olson TS, Ley K.
Immunity
2005
L-selectin,
alpha 4 beta 1, and alpha 4 beta 7 integrins participate
in CD4+ T cell recruitment to chronically inflamed small
intestine. Rivera-Nieves J, Olson
T, Bamias G, Bruce A, Solga M, Knight RF, Hoang S, Cominelli
F, Ley K.
J Immunol.
2005
CXCR2-
and E-Selectin-induced Neutrophil Arrest during Inflammation
In Vivo. Smith ML, Olson TS, Ley
K.
J Exp Med.
2004
Critical
role of macrophage 12/15-lipoxygenase for atherosclerosis
in apolipoprotein E-deficient mice. Huo Y, Zhao L, Hyman MC,
Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA,
Smith DF, Clarke S, Srinivasan S, Hedrick CC, Pratico
D, Witztum JL, Nadler JL, Funk CD, Ley K.
Circulation
2004
A
novel method to analyze leukocyte rolling behavior in
vivo. Dunne JL, Goobic AP, Acton
ST, Ley K.
Biol. Proced. Online
2004
Expanded
B cell population blocks regulatory T cells and exacerbates
ileitis in a murine model of Crohn disease. Olson TS, Bamias G, Naganuma
M, Rivera-Nieves J, Burcin TL, Ross W, Morris MA, Pizarro
TT, Ernst PB, Cominelli F, Ley K.
J. Clin. Invest.
2004
Binding
and detachment dynamics of microbubbles targeted to
P-selectin under controlled shear flow. Takalkar AM, Klibanov
AL, Rychak JJ, Lindner JR, Ley K.
J. Control Release
2004
Autoperfused
mouse flow chamber reveals synergistic neutrophil accumulation
through P-selectin and E-selectin. Smith ML, Sperandio M,
Galkina EV, Ley K.
J. Leukoc. Biol.
2004
Targeted Disruption of cd73 /Ecto-5'-Nucleotidase Alters Thromboregulation and Augments Vascular Inflammatory Response.
Patrycja Koszalka, Burcin Özüyaman, Yuqing Huo, Alma Zernecke, Ulrich Flögel, Norbert Braun, Anja Buchheiser, Ulrich K.M. Decking, Michael L. Smith, Jean Sévigny, Adrian Gear, Artur-Aron Weber, Andrei Molojavyi, Zhaoping Ding, Christian Weber, Klaus Ley, Herbert Zimmermann, Axel Gödecke, Jürgen Schrader
Circ. Res.
2004
Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. M. Angelica Martinez Gakidis,
Xavier Cullere, Timothy Olson, Julie L. Wilsbacher, Bin Zhang, Sheri L. Moores, Klaus Ley, Wojciech Swat, Tanya Mayadas, and Joan S. Brugge
Eur. J. Cell Biol.
2004
Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution. David S. Long, Michael L. Smith, Axel R. Pries, Klaus Ley, and Edward R. Damiano
Proc Natl Acad Sci
2004
Alpha4beta1 integrin (VLA-4) blockade attenuates both early and late leukocyte recruitment and neointimal growth following carotid injury in apolipoprotein E (-/-) mice. Kurt G. Barringhaus, J. William Phillips, Jayant S. Thatte,
J. Vasc. Res.
2004
Critical role of platelet P-selectin in the response to arterial injury in apolipoprotein-E-deficient mice. David Manka; S. Bradley Forlow; John M. Sanders; Debra Hurwitz; Daniel K. Bennett; Samuel A. Green; Klaus Ley; Ian J. Sarembock
Arterioscler. Thromb. Vasc. Biol.
2004
Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin. Michael L. Smith, Markus Sperandio, Elena V. Galkina and Klaus Ley
J Leukoc Biol
2004
Rosiglitazone reduces the accelerated neointima formation after arterial injury in a mouse injury model of type 2 diabetes. J. William Phillips, MD; Kurt G. Barringhaus, MD; John M. Sanders, BS; Zandong Yang, MD; Meng Chen, MD; Sean Hesselbacher, BS; Ann C. Czarnik, BS; Klaus Ley, MD; Jerry Nadler, MD; Ian J. Sarembock, MB, ChB, MD
Circulation
2003
Circulating
activated platelets exacerbate atherosclerosis in apolipoprotein
E deficient mice. Huo, Y., Schober, A.,
Forlow, S.B., Smith, D.F., Hyman, M.C., Jung, S., Littman,
D.R., Weber, C., Ley, K.
Nature Medicine
2003
Expression
of CXCL16 in human T cells (letter to the editor). Shashkin, P., Simpson,
D., Chesnutt, B., Ley, K.
Arteriosclerosis, Thromb.
and Vasc. Biol.
2003
LFA-1
is required for retention of effector CD8 T cells in
mouse lungs. Thatte, J., Dabak, V.,
Williams, M.B., Braciale, T.J., Ley, K.
Blood
2003
P-selectin
glycoprotein ligand-1 mediates L-selectin dependent
rolling in venules. Sperandio, M., Smith,
M.L., Forlow, S.B., Olson, T.S., Xia, L., McEver, R.P.,
Ley, K.
J.Exp. Med.
2003
Single
injection of P-selectin or PSGL-1 monoclonal antibody
blocks neointima formation after arterial injury in
apolipoprotein-E deficient mice. Phillips JW, Barringhaus
KG Sanders JM, Hesselbacher SE, Czarnik AC, Manka D,
Vestweber D, Ley K, Sarembock IJ.
Circulation
2003
Local-pooled-error test for identifying
differentially expressed genes with a small
number of replicated microarrays. Nitin Jain, Jayant Thatte, Thomas Braciale, Klaus Ley,
Michael O’Connell and Jae K. Lee
Bioinformatics
2003
Vascular
protection by estrogen in ischemia-reperfusion injury
requires endothelial nitric oxide synthase. Prorock, A.J., Hafezi-Moghadam,
A., Laubach, V.E., Liao, J., Ley, K.
Am. J. Physiol.
2003
Mac-1, but Not LFA-1, Uses Intercellular Adhesion Molecule-1 to Mediate Slow Leukocyte Rolling in TNF-
Jessica L. Dunne, Robert G. Collins, Arthur L. Beaudet, Christie M. Ballantyne, and
Klaus Ley
J Immunol
2003
Acute
cardiovascular protective effects of corticosteroids
are mediated by non-transcriptional activation of endothelial
nitric oxide synthase. Hafezi-Moghadam, A., Simoncini,
T., Yang, Z., Limbourg, F.P., Plumier, J.-C., Rebsamen,
M.C., Hsieh, C.M., Chui, D.S., Thomas, K.L., Prorock,
A.J., Laubach, V.E., Moskowitz, M.A., French, B.A.,
Ley, K., Liao, J.K.
Nature Medicine
2002
Automatic
tracking of rolling leukocytes in vivo. Acton, S.T., Wethmar,
K., Ley, K.
Microvascular Research
2002
Control
of leukocyte rolling velocity in TNF-alpha-induced inflammation
by LFA-1 and Mac-1. Dunne, J.L., Ballantyne,
C.M., Beaudet, A.L., Ley, K.
Blood
2002
Deposition
of platelet RANTES triggering monocyte recruitment requires
P-selectin and is involved in neointima formation after
arterial injury. Schober, A., Manka, D.,
von Hundelshausen, P., Huo, Y; Hanrath, P., Sarembock,
I.J., Ley, K., Weber, C.
Circulation
2002
L-selectin
is required for fMLP- but not C5a-induced sequestration
of neutrophils in the pulmonary circulation. Olson, T.S., Singbartl,
K., Ley, K.
Am. J. Physiol.: Regulatory,
Integrative and Comparative Physiology
2002
P-selectin
Glycoprotein Ligand-1-deficient mice have impaired leukocyte
tethering to E-selectin under flow. Xia, L., Sperandio, M.,
Yago, T., McDaniel, J.M., Cummings, R.D., Pearson-White,
S., Ley, K., McEver, R.P.
J. Clin. Invest.
2002
Severely
reduced neutrophil adhesion and impaired host defense
against fecal and commensal bacteria in CD18-/-P-selectin-/-
double null mice. Forlow, S.B., Foley, P.L.,
Ley, K.
FASEB J.
2002
Sialyltransferase
specificity in selectin ligand formation. Ellies, L.G., Sperandio,
M., Underhill, G.H., Yousef, J., Smith, M.L., Priatel,
J.J., Kansas, G.S., Ley, K., Marth, J.D.
Blood
2002
T
cell requirement for the development of chronic ulcerative
dermatitis in E- and P-selectin deficient mice. Forlow, S.B., White, E.J.,
Thomas, K., Bagby, G.J., Foley, P.L., Ley, K.
J. Immunol.
2002
Tracking
leukocytes in vivo with shape and size constrained active
contours. Ray, N., Acton, S.T.,
Ley, K.
IEEE Transactions on Medical
Imaging
2002
Viscosity-independent
velocity of neutrophils rolling on P-selectin in vitro
or in vivo. Smith, M.L., Smith, M.J.,
Lawrence, M.B., Ley, K.
Microcirculation
2002
Binding of function-blocking mAbs to mouse and human P-selectin glycoprotein ligand-1 peptides with and without tyrosine sulfation. Aravinda Thatte, Scott Ficarro, Karen R. Snapp, Martin K. Wild, Dietmar Vestweber, Donald F. Hunt, and Klaus F. Ley
J Leukoc Biol
2002
A
CD2-GFP Transgenic mouse reveals VLA-4-dependent CD8+
Lymphocyte Rolling in the Inflamed Microcirculation. Singbartl, K., Thatte,
J., Smith, M.L., Day, K., Ley, K.
J. Immunol.
2001
Dermal
and pulmonary inflammatory disease in E/P-selectin double-null
mice is reduced in triple-selectin-null mice. Collins, R.G., Jung, U.,
Ramirez, M., Bullard, D.C., Hicks, J., Smith, C.W.,
Ley, K., Beaudet, A.L.
Blood
2001
Differential
requirements for core2 glucosaminyltransferase for endothelial
L-selectin ligand function in vivo. Sperandio, M., Forlow,
S.B., Thatte, J., Ellies, L.G., Marth, J.D., Ley, K.
J. Immunol.
2001
Essential
role of neutrophils in germ cell-specific apoptosis
following ischemia/reperfusion injury of the mouse testis. Lysiak, J.L., Turner,
S.D., Nguyen, Q.A., Singbartl, K., Ley, K., Turner,
T.T.
Biology of Reproduction
2001
Increased
granulopoiesis through interleukin-17 and granulocyte
colony-stimulating factor in leukocyte adhesion molecule-deficient
mice. Forlow, S.B., Schurr,
J.R., Kolls, J.K., Bagby, G.J., Schwarzenberger, P.S.,
Ley, K.
Blood
2001
L-selectin
shedding regulates leukocyte recruitment. Hafezi-Moghadam, A., Thomas,
K.L., Prorock, A.J., Huo, Y., Ley, K.
J.Exp.Med.
2001
Platelet,
not endothelial P-selectin is critical for neutrophil-mediated
acute postischemic renal failure. Singbartl, K., Forlow,
S.B., Ley, K.
FASEB J.
2001
RANTES
deposition by platelets triggers monocyte arrest on
inflamed and atherosclerotic endothelium. von Hundelshausen, P.,
Weber, K.S.C., Huo, Y., Proudfoot, A.E.I., Nelson, P.,
Ley, K., Weber, C.
Circulation
2001
Selectin-independent
leukocyte rolling and adhesion in mice deficient in
E-, P-, and L-selectin and ICAM-1. Forlow, S.B., Ley, K.
Am. J. Physiol.
2001
Severe
impairment of leukocyte rolling in core 2 glucosaminyltransferase
deficient mice. Sperandio, M., Thatte,
A., Foy, D., Ellies, L., Marth, J.D., Ley, K.
Blood
2001
The
chemokine KC, but not MCP-1 triggers arrest of monocytes
in carotid arteries with early atherosclerotic lesions. Huo, Y., Forlow, S.B.,
Weber, C., Jung, S. Littman, D.R., Ley, K.
J. Clin. Invest.
2001
Ultrasound
assessment of inflammation and renal tissue injury with
microbubbles targeted to P-selectin. Lindner JR, Song J, Christiansen
J, Klibanov AL, Xu F, Ley K.
Circulation
2001
Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of crohn's disease in mice. R. Burns, J. Rivera-Nieves, C. Moskaluk, S. Matsumoto, F. Cominelli, K. Ley
Gastroenterology
2001
Absence
of P-selectin but not ICAM-1 limits neointimal growth
after arterial injury in apoliprotein-E (apoE)-deficient
mice. Manka, D., Collins, R.,
Ley, K., Beaudet, A.L., Sarembock, I.J.
Circulation
2000
Blocking
P-selectin protects from ischemia-reperfusion induced
severe acute renal failure. Singbartl, K., Green,
S.A., Ley, K.
FASEB J.
2000
Delayed
onset of inflammation in protease-activated receptor-2
(PAR-2) deficient mice. Lindner, J.R., Kahn, M.L.,
Coughlin, S.R., Sambrano, G.R., Schauble, E., Bernstein,
D., Foy, D., Hafezi-Moghadam, A., Ley, K.
J. Immunol.
2000
Intercellular
Adhesion Molecule-1 (ICAM-1) is required for chemoattractant-induced
leukocyte adhesion in resting, but not inflamed venules
in vivo. Foy, D.S., Ley, K.
Microvascular Research
2000
Leukocyte
arrest during cytokine-dependent inflammation in vivo Kunkel, E.J., Dunne, J.L.,
Ley, K.
J. Immunol
2000
Microbubble
persistence in the microcirculation during ischemia-reperfusion
and inflammation: integrin- and complement-mediated
adherence to activated leukocytes. Lindner, J.R., Coggins,
M.P., Kaul, S., Klibanov, A.L., Brandenburger, G.H.,
Ley, K.
Circulation 101
2000
Noninvasive
imaging of inflammation by ultrasound detection of phagocytosed
microbubbles. Lindner, J.R., Dayton,
P.A., Coggins, M.P., Ley, K., Song, J., Ferrara, K.,
Kaul, S.
Circulation
2000
Noninvasive
in vivo magnetic resonance imaging of injury-induced
neointima formation in the carotid artery of the apolipoprotein-E
null mouse. Manka, D., Gilson, W.,
Sarembock, I.J., Ley, K., Berr, S.S.
J. Magnetic Resonance
Imaging
2000
Noninvasive
ultrasound imaging of inflammation using microbubbles
targeted to activated leukocytes. Lindner, J.R., Song, J.,
Xu, F., Klibanov, A.L., Singbartl, K., Ley, K., Kaul,
S.
Circulation
2000
Protection
from ischemia-reperfusion induced severe renal failure
by blocking E-selectin. Singbartl, K, Ley, K.
Critical Care Medicine
2000
Role
of Vascular Cell Adhesion Molecule-1 (VCAM-1) and fibronectin
connecting segment-1 in monocyte rolling and adhesion
on early atherosclerotic lesions. Huo, Y., Hafezi-Moghadam,
A., Ley, K.
Circ. Res.
2000
Severe
inflammatory defect and reduced viability in CD18 and
E-selectin double mutant mice. Forlow, S.B., White, E.J.,
Barlow, S.C., Feldman, S.H., Lu, H., Bagby, G.J., Beaudet,
A.L., Bullard, D.C., Ley, K.
J. Clin. Invest.
2000
The
CD24/P-selectin binding pathway initiates lung arrest
of human A125 adenocarcinoma cells. Friederichs, J., Zeller,
Y., Hafezi-Moghadam, A., Mecke, C., Gröne, H.-J., Ley,
K., Altevogt, P.
Cancer Research
2000
Vascular
protective effects of oestrogen mediated by phosphatidylinositol
3-OH kinase. Simoncini, T., Hafezi-Moghadam,
A., Brazil, D., Ley, K., Chin, W.W., Liao, J.K.
Nature
2000
Review Articles in Peer-Reviewed Journals
Title
Author(s)
Journal
Publication
Year
Getting to the site of inflammation: the leukocyte adhesion cascade updated. Klaus Ley, Carlo Laudanna
Nat Rev Immunol .2007
Vascular Adhesion Molecules in Atherosclerosis. Galkina E, Ley K. Arterioscler Thromb Vasc Biol .2007
Platelet-neutrophil-interactions: Linking hemostasis and inflammation Alexander Zarbock, Renata K. Polanowska-Grabowska and Klaus Ley
Blood Reviews
2007
Effects of Native and Modified Low-Density Lipoproteins on Monocyte Recruitment in Atherosclerosis. Gleissner CA, Leitiniger N, Ley K.
Hypertension 2007
Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow A. L. Klibanov , J. J. Rychak, W. C. Yang, S. Alikhani, B. Li, S. Acton, J. R. Lindner, K. Ley, S. Kaul
Contrast Media & Molecular Imaging
2006
Analysis of Leukocyte Rolling In Vivo and In Vitro Markus Sperandio, John Pickard, Sunil Unnikrishnan, Scott T. Acton and Klaus Ley
Methods in Enzymology
2006
Neutrophil-Regulatory Tn Lymphocytes
Ley K, Smith E, Stark MA.
Immunol Res. 2006
Leukocyte recruitment and vascular injury in diabetic nephropathy. Elena Galkina and Klaus Ley
J Am Soc Nephrol
2006
Macrophage differentiation
to foam cells. Shashkin P, Dragulev B,
Ley K.
Curr Pharm Des.
2005
Bench-to-bedside review:
acute respiratory distress syndrome - how neutrophils
migrate into the lung. Reutershan J, Ley K.
Crit Care
2005
L-selectin:
mechanisms and physiological significance of ectodomain
cleavage. Smalley DM, Ley K.
J Cell Mol Med.
2005
The physiology and pathophysiology of P-selectin. Sperandio M., Ley K.
Modern Aspects in Immunobiology
2005
L-selectin in inflammation, infection and immunity Nikolai A. Raffler, Jesús Rivera-Nieves and Klaus Ley
Drug Discovery Today: Therapeutic Strategies
2005
Role
of platelets in the development of atherosclerosis. Huo Y, Ley KF.
Trends Cardiovasc. Med.
2004
Leukocyte
recruitment and acute renal failure. Singbartl K, Ley K.
J. Mol. Med. 2004
2004
Trafficking of natural
killer cells. Morris MA, Ley K.
Curr. Mol. Med.
2004
Selectins in T-cell recruitment
to non-lymphoid tissues and sites of inflammation. Ley K, Kansas GS.
Nat. Rev. Immunol.
2004
Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation. Dumont AS, Dumont RJ, Chow MM, Lin CL, Calisaneller T, Ley KF, Kassell NF, Lee KS.
Neurosurgery
2003
The role of selectins in inflammation and disease Klaus Ley
Trends in Molecular Medicine
2003
The role of inflammation in vascular injury and repair. Davis C, Fischer J, Ley K, Sarembock IJ.
J Thromb Haemost. 2003
Arrest Chemokines
Klaus Ley
Microcirculation
2003
Integration of inflammatory signals by rolling neutrophils Klaus Ley
Immunological Reviews
2002
Chemokines and chemokine receptors in leukocyte trafficking
Timothy S. Olson and Klaus Ley
Am J Physiol Regul Integr Comp Physiol
2002
Pathways and Bottlenecks in the Web of Inflammatory Adhesion Molecules and Chemoattractants Ley K.
Immunologic Research
2001
Adhesion molecules and atherogenesis. Y. Huo and K. Ley
Acta Physiol. Scand.
2001
La Jolla Institute for Allergy & Immunology Faculty website klaus@liai.org
2,3-Sialyltransferase-IV is essential for L-selectin ligand function in inflammation
is required for chemokine-induced, sustained adhesion under flow in vivo
-Induced Inflammation.