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Christian Gleissner, M.D.
Research Interests: Atherosclerosis represents the leading cause of morbidity in Western countries. Monocyte adhesion to the vascular endothelium and transmigration into the vessel wall followed by differentiation into monocytes, macrophages, and foam cells are key events in atherogenesis. Differentially modified forms of low density lipoprotein (native LDL, minimally modified LDL, and oxidized LDL) have differential effects on these events. Based on Affymetrix gene arrays investigating LDL effects on monocytes and monocyte-derived macrophages, we study different aspects of foam cell differentiation. By phenotypically and functionally characterizing these cells we intend to gain new insights into function and fate of monocytes and monocyte-derived cells in atherosclerosis thereby unveiling diagnostic biomarkers as well as potential therapeutic targets.
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